Hello everyone, I get asked ALL THE TIME when you should be using Th1 support vs Innate Immune support so here are my thoughts.

Questions: When would you use the Th1 support vs. the innate immune support? Would you use them together for an acute ie. viral infection? Would you use one over the other to enhance Th1 polarization in a chronic lyme infection? Which one for suppressing Th17 response? Can you use the ones for Th1 polarization with the immune balance at the same time to decrease an autoimmune flair while trying to suppress a th17 response, or would that be counterproductive?

Response: I focus on supporting the Th1 response and NK cells (using astragalus, andrographis, and ganoderma, aka reishi) together all the time. Th1 cells and NK cells both make interferon gamma (IFNg). IFNg inhibits Th17 cell production of the effector cytokines that drive autoimmune tissue destruction. And, Th1 cells and NK cells also drive anti-viral and anti-bacterial immunity. Th1 cell activation also inhibits Th2 response. Th2 response drives allergy, hollow space dysfunction, etc.
I tend to follow a three step process:

1. Balance T cell polarization issues, supporting Th1 response and NK cell activation and downregulating (modulating) excessive Th2 response. I often use perilla leaf extract to reinforce the downregulation of Th2 dominance.
2. Reduce the Inflammation-Autoimmune coactivation process (inhibit the NFkB-STAT3 co-activation process) using curcuminoids, resveratrol, black ginger, quercetin and similar substances.
3. Personalize the process, addressing the rest of the factors in the case, including GI function, pathogen burdens, low wbc counts, etc.