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A relative of mine (my aunt) who is a 68 year old woman has intractable methane and hydrogen gas producing SIBO and a lot of nausea. She has done 2 courses of Rifaximin plus neomycin from her ND. Her ND also put her on a biofilm disruptor- Biocidin, in addition to a formulation with Glutamine/aloe and vagal toning with breathwork, gargling, and bitter herbs after meals, as well as berberine, which she is tolerating, and coconut oil daily.
Her gas/bloating improved but not resolved, and nausea has been ongoing (mostly in mornings). Repeat SIBO test was surprising: Still positive for both methane and H2! !!!
Other than taking a third round of Rifaximin (this time 3x daily) + Neo+ Biocidin, are there any additional considerations for eradication? I am worried about the significant nausea the 3 x daily dosing will cause. She has been losing weight. Any suggestions on the intractable nausea, and just how refractory she is.
thank you so much!
Methane is known to greatly slow gut motility.
I’d recommend the following:
(1) make sure her thyroid functioning is adequate. If not, her gut motility will be further slowed, worsening her SIBO. (Explaining how to do this properly is beyond the scope of this reply, but it involves more than just checking a TSH and a T4. Seek a good functional medicine practitioner.)
(2) consider use of a promotility agent – Iberogast or Low-dose naltrexone are good choices.
(3) biofilm disruptor between meals
(4) digestive enzymes (during meals) may be helpful for some people. Some people even benefit from elemental diets, but I find this is generally overkill for most.
(5) A low-FODMAPS diet (or GAPS diet or SCD – they’re all fairly equivalent) can be helpful.(6)Have her do TVNS to improve vagal tone and MMC.
(7)once you’ve got all of the above lined up and rolling, THEN she can use the antibiotics for the couple of days if needed. If you want to spare the patient (or her insurance company) the $1600 cost of rifaximin (give or take, last I checked), be aware that there are some reasonable alternative herbal agents that work just as well and are MUCH less expensive. I’m personally fond of using Candibactin AR and Candibactin BR.
Check out siboinfo.com for more info. There are other SIBO sites (possibly even better ones), but siboinfo.com will get you off to a good start.
to continue this:
I have also found that SIBO is frequently associated with hormone toxicity. The Dutch test will confirm or negate this. Copper toxicity and vitamin C depletion/deficiency may add to the problem of poor valve integrity. SIBO Rebuild is a great product for post-treatment as is Sunbutyrate from Pure Encapsulations.
https://PUBMED.NCBI.NLM.NIH.GOV/18338309/
A few other things:
1. Be sure the patient has enough choline and doesn’t have snp’s that might promote the need for additional choline (PEMT and MTHFD1). Inadequate choline > inadequate acetyl choline > vagal motor outflow won’t create its final effects in the GI tract (reduction of inflammation and promotion of motility) if there’s no Ach release when vagal motor outflow fires up.
2. Be sure there’s no candida, as the shift toward Th2 that the candida cultivates will diminish surveillance against the whole range of unfavorable flora.
3. Nausea can be associated with hypoglycemia. If that’s the case here, you’ll need to be concerned about lack of fuel for M1 macrophages, and again a need to improve surveillance.
4. Pertaining to #3 above, gluconeogenesis in the liver is inhibited by STAT3, driven by IL-6. Vagal motor outflow is supposed to block Kupfer cell IL-6 production, which shuts this down.
5. If the patient is insulin resistant, the extra insulin will inhibit vagal motor outflow.Hope this helps 🙂
What seem to be the BEST probiotics for sibo? I am currently taking Genestra HMF Intensive 25 billion.
Also, I know garlics gives sibo but at the same time it is an antifungal. Is it still best to avoid it regard less?
You shouldn’t be on probiotics with SIBO until you’ve cleared out the overgrowth and improved vagal motor tone. Bacillus coagulans could be helpful.
Garlic is great but if it’s aggravating you, you have to avoid it.
Okay, I do not take the Genestra all the time but here and there when I feel a tiny cold coming in. I meant to say I currently have at home Genestra HMF Intensive 25 billion. I was told not to take due to sibo.
When you had sibo or most of your clients have do you advice them to take Bacillus coagulans? Or is best to avoid for now? I know and have heard that string of probiotic does help. I am just curious to know.(:
How do I fix sibo? I must support the liver, do a good parasite/ candida cleanse, reduce stress? I know this has to do with the gut and brain connection. I also know going on a low fodmap adding antifungals such as berberine would be part of the sibo short term diet to fix that up? I want to know advice and what tips and how MOST people remission from sibo.
I recommend different strains depending on their issue. Sometimes I suggest HMF Intensive 500, sometimes SBO probiotics… it really depends. baciallus coagulans can help but it wont repopulate in the gut.
I have answered another FORUM topic on SIBO and what needs to be done so perhaps try searching it in the search bar.
Yes UNDAs are safe ALL the time.
SBO is from Dr. Axe I used to have them, but they are so strong for me. I do not like it lol. I bought them like 2 years ago.
I already did maybe I found it. Is it the one with the long typing?
How long can it take to recover from sibo? I know everyone is different. But from what you have seen in general? I know sibo is also from candida. I am (as you know) supporting my liver and now slowly i’m adding antifungals to get ride of sibo.
What do you advice most clients? to keep the sugar intake low? I eat quinoa a lot and blueberries.
It could take months to a year plus to clear!
Here is the SIBO link: https://holisticspring.org/topic/sibo/
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