First of all, I am not a doctor so there is PLENTY I don’t know about Lyme disease and the testing methods used. That being said, I have taken courses and read a lot of material and it seems that while most the tests for diagnosing Lyme are mainly poor, PCR testing for Lyme seems to be a better option since it is a fingerprint style test, and therefore more definitive when abnormal.
The paper below and those related to it suggest that successful clearance of Lyme requires a healthy Th1 response. Those with neuroborreliosis have IL-17 (a Th17 cytokine) in CSF. This means that making sure you have a balanced immunity to fight off lyme is essential!
Paper: Indications of Th1 and Th17 responses in cerebrospinal fluid from patients with Lyme neuroborreliosis: a large retrospective study
Journal of Neuroinflammation — Henningsson AJ, et al. | May 02, 2011