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Sorry last question for now I promise lool!
My sister can’t take L-glutamine without getting a negative reaction. She doesn’t actually have an allergy to it but it doesn’t sit well with her. What can she take for the gut instead? She usually gets anxiety, sometimes skin rashes but also insomnia.
So here are my thoughts:
I immediately think about the interconversion of glutamine and glutamate. They convert in a loop cycle (1 converts into the other), so raising L-glutamine levels in the body will also have the potential to increase the pool of glutamate. Glutamate can be neuroexcitotoxic, if it cannot be converted into other things, mainly GABA (neurotransmitter). This requires GAD (glutamic acid decarboxylase).
You don’t need to have GAD antibodies to be simply not great at the conversion. There is variability there, one person to another, based on genetics.
The negative effects of glutamate stimulation can be reduced with magnesium and glycine, so giving magnesium glycinate daily with the glutamine may help your sister.
This is not a glutamine allergy (IgE response) or sensitivity (IgG response). It’s a biochemical process in the body that isn’t antibody based.
Interesting! My sister had a bad reaction when she tried L-glut, it made her bloat extremely and painfully. Would your explanation above describe what she was experiencing as well? 😮
Marissa it could but if she is getting bloated from glutamine, she probably has incredibly low stomach acid levels and SIBO.
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