Hey great question! To be honest, i know nothing about tatoos or the removal process so not sure if that is what could be causing it. BTD can help with depression but only if you’re addressing the root of it. it could be a gut-related issues, genetic SNP issues, nutrient deficinecy issue, congestion issues, etc. figuring out the root and then taking the appropriate BTDs and Gemmos will give the best results. She could try GABA and melatonin along with st johns wart potentially for basic support!